Indoxacarb: A Broad-Spectrum Oxadiazine Insecticide

2025-08-21 13:56

Technical Introduction

Indoxacarb (IUPAC: methyl(E)-7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate) is a novel oxadiazine insecticide with contact and ingestion activity against a wide range of chewing pests. It works by blocking sodium ion channels in the insect nervous system, causing paralysis and death.

  • Mode of Action: Sodium channel blocker (IRAC Group 22A), leading to nervous system failure in target pests.

  • Systemicity: Primarily a contact and ingestion insecticide, with some translaminar activity.

  • Target Spectrum: Effective against caterpillars, bollworms, armyworms, leafrollers, and certain Lepidopteran larvae.


Applications

  • Field Crops:

    • Controls Helicoverpa spp., Spodoptera spp., and other caterpillars in cotton, maize, and soybean.

  • Vegetables:

    • Applied on tomatoes, peppers, cabbage, and eggplants to manage leaf-eating caterpillars.

  • Ornamental Plants:

    • Protects greenhouse crops from chewing pests like caterpillars and leaf miners.

  • Integrated Pest Management (IPM):

    • Compatible with beneficial insects due to selective action against Lepidopteran pests.


Advantages

  • Selective Toxicity: Targets chewing pests while being safe for pollinators and natural enemies.

  • Fast Knockdown: Causes rapid paralysis and mortality in larvae.

  • Translaminar Activity: Provides protection for new leaves after application.

  • IPM Compatible: Can be rotated with other insecticides to prevent resistance development.

  • Flexible Formulations: Available in water-dispersible granules, suspension concentrates, and emulsifiable concentrates.


Specifications (Typical Parameters)

ParameterDescriptionTypical Value
Chemical NameIndoxacarb
Chemical ClassOxadiazine insecticide (IRAC 22A)
Chemical FormulaC₂₂H₁₈ClF₃N₃O₇
Molecular Weight~527.0 g/mol
AppearanceWhite to light brown crystalline powder
Purity (TC)≥ 95%
Common FormulationsWater-dispersible granules (WG), suspension concentrate (SC), emulsifiable concentrate (EC)15% WG, 30% SC
Mode of ActionSodium channel blocker; contact and ingestion activity
Target PestsCaterpillars, bollworms, armyworms, leafrollers
Residual Activity7–14 days depending on crop and pest pressure
ToxicityLow mammalian toxicity (oral LD₅₀ in rats >5000 mg/kg); safe for bees when applied properly

FAQ

Q1: How does Indoxacarb kill pests?
A: It blocks sodium channels in insect nerves, causing paralysis and death.

Q2: Is Indoxacarb effective against sucking pests?
A: No. It is primarily effective against chewing pests like caterpillars and bollworms.

Q3: Can Indoxacarb be used in IPM programs?
A: Yes. Its selective toxicity and low impact on beneficial insects make it IPM-friendly.

Q4: Is Indoxacarb fast-acting?
A: Yes. It causes rapid paralysis, but full colony-level effects may take several days.

Q5: Can Indoxacarb be mixed with other pesticides?
A: Yes, but always check label compatibility to avoid reduced efficacy or phytotoxicity.

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