Oligopeptide-1 (EGF): A Regenerative Peptide for Skin Repair and Anti-Aging

Technical Introduction

Oligopeptide-1, also known as Epidermal Growth Factor (EGF), is a short chain peptide consisting of 53 amino acids that plays a critical role in cell growth, differentiation, and repair.

It works by binding to EGF receptors (EGFR) on the cell surface, triggering intracellular signaling cascades such as the MAPK and PI3K/AKT pathways, which lead to cellular regeneration, increased collagen synthesis, and enhanced wound healing.

Originally discovered by Dr. Stanley Cohen (Nobel Prize in Physiology/Medicine, 1986), EGF has become one of the most impactful bioactive peptides in dermatology and cosmeceuticals.

• INCI Name: Oligopeptide-1

• Also Known As: Epidermal Growth Factor (EGF)

• Origin: Recombinant biotechnology (produced in E. coli or yeast)

• Molecular Weight: ~6.2 kDa

• Appearance: White to off-white powder or aqueous solution

• Solubility: Water-soluble

• Stability: Sensitive to heat and enzymatic degradation; stable under cold storage

Applications

1. Cosmetics & Skincare

• Anti-aging creams & serums → Stimulates fibroblast activity to reduce wrinkles and fine lines.

• Brightening products → Promotes skin renewal for even skin tone.

• Post-procedure serums → Enhances recovery after microneedling, laser, or chemical peels.

• Hydration & repair creams → Supports skin barrier function.

2. Medical & Dermatological Use

• Wound healing accelerant → Used in burn treatments and ulcer healing.

• Tissue engineering & regenerative medicine → Supports cell proliferation in grafts.

• Scar-reduction formulations → Reduces hypertrophic scarring.

3. Hair Care

• Scalp serums → Promotes follicle regeneration and hair growth.

• Anti-hair loss products → Supports healthier scalp environment.

✅ Advantages

• Stimulates cell regeneration → Promotes faster repair of damaged skin.

• Boosts collagen and elastin → Improves firmness and elasticity.

• Accelerates wound healing → Beneficial for medical and cosmetic recovery.

• Reduces wrinkles & fine lines → Proven anti-aging performance.

• Evens skin tone → Encourages new, healthy cell turnover.

• Synergistic with hyaluronic acid → Enhances penetration and hydration.

⚙️ Technical Specifications (Cosmetic Grade)

⚠️ Safety & Regulatory Notes

• Topical Use: Safe at cosmetic concentrations (ppm levels).

• Toxicity: Non-cytotoxic at recommended usage levels.

• Regulatory Status: Approved for cosmetic use in EU, USA, Korea, Japan, and China.

• Formulation Tips: Add during cool-down (<40 °C) phase; avoid protease-rich environments that degrade peptides.

❓ FAQ

Q1: What is the difference between Oligopeptide-1 and EGF?
They are the same; in cosmetics, EGF is labeled as Oligopeptide-1 under INCI naming.

Q2: How soon are results visible?
Noticeable improvement in skin texture and hydration within 2–4 weeks, with wrinkle reduction in 8–12 weeks.

Q3: Can it be combined with retinol or vitamin C?
Yes, but for best results, use EGF in the evening and actives like retinol/vitamin C at different times to avoid degradation.

Q4: Is Oligopeptide-1 safe for sensitive skin?
Yes, it is well tolerated, even on delicate post-treatment skin.

Q5: What products typically use EGF (Oligopeptide-1)?
Found in serums, ampoules, masks, scar-reduction creams, and scalp growth tonics.